Manfred Brockhaus, John L. Magnani, M. Herlyn
Sep 1, 1982
Citations
2
Influential Citations
129
Citations
Quality indicators
Journal
Archives of biochemistry and biophysics
Abstract
Abstract Four hybridomas obtained from mice immunized with human adenocarcinomas of colon or stomach produce antibodies that bind specifically in solid-phase radioimmunoassay to the ceramide pentasaccharide that contains the lacto-N-fucopentaose III sequence of sugars. Binding of the antibodies to the glycolipid is inhibited by lacto-N-fucopentaose III, but not by structurally related oligosaccharides. The antibodies bind to glycolipids of erythrocytes, granulocytes, and certain normal and malignant tissues.