Jin’an Zhao, Yan Guo, Jiyong Hu
Dec 14, 2015
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Polyhedron
Abstract
Abstract Two Zn(II) complexes bearing benzimidazole-based derivatives, namely Zn2(p-2-bmb)2 (NO3)4 (1) and Zn(p-2-bmp)2Cl2 (2) (p-2-bmb = 1-((2-(pyridin-2-yl)-1-benzoimidazol-1-yl)methyl)-1H-benzotriazole, p-2-bmp = 1-((2-(pyridine-2-yl)-1H-benzoimidazol-1-yl)methyl)-1H-pyridine) were constructed and their biological activities against four human cancer cell lines were estimated. Compared with complex 2, in cytotoxicity research complex 1 showed higher cytotoxic properties in vitro against different carcinoma cells, especially for SHSY5Y cells. The interactions of complex 1 with calf thymus DNA were studied by spectroscopic techniques, including absorption and fluorescence, which showed the binding mode of 1 is not the classical intercalation binding. The optimum antiproliferative activity of complex 1 in SHSY5Y cells was found to involve G0/G1 phase arrest of the cell cycle. In addition, the morphological changes and membrane permeability changes also provide evidence that 1 could induce apoptosis.