A. El‐Shekeil, A. Obeid, Sama A. Z. Al-Aghbari
Sep 30, 2012
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Journal
European Journal of Chemistry
Abstract
New benzimidazole derivatives, namely, ( N -(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), ( N -(3,4-dimethoxyphenyl)methylene]-1 H -benzimidazol-2-amine (2b), and ( N -(3,4,5-trimethoxyphenyl)methylene]-1 H -benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1 H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.