J. P. Long, H. Keasling
Oct 1, 1954
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
Fourteen 3-hydroxy piperidine analogs have been compared to atropine and similar drugs for anticholinergic activity in six tests involving dog, rat, and rabbit. Two of these analogs, JB-323 (N-ethyl-3-hydroxy iperidine benzilate methobromide) and JB-340 (N-methyl-3-hydroxy piperidine Lnzilate methobromide), are approximately as active as atropine. The 3-hydroxy piperidines, in general, are relatively more active on the intestinal preparations than in inhibiting acetylcholine depressor responses, pilocarpine induced salivation, or β-methacholine induced lacrimation.