A. Hassouna, H. Allam
Oct 1, 2001
Citations
0
Influential Citations
1
Citations
Journal
Vascular
Abstract
Reports on phenindione toxicity have limited its use as an oral anticoagulant. Our aim was to evaluate its risks in pregnant women. Thirty-one pregnancies in 29 women with mitral (±aortic) St. Jude mechanical valves were followed-up prospectively. Eighteen patients received phenindione. Eleven patients (37.9%) received in addition to phenindione 225 mg dipyridamole. which was given in three doses. The target INR. was 2.5-3.5 in the former and 2-2.5 in the latter treatment. A fortnight before delivery. intravenous heparinotherapy was substituted. There were no maternal complications. apart from a single postpartum hemorrhage (3.2%). After the deliveries the results were: 26 mature babies (83.9%). 3 premature babies (9.7%) and 2 cases of stillbirth (6.4%). Outcome was dose related; being 57.2±20.9 mg/day for mature babies and 82.5±11.2 mg/day for prematures and stillbirths (P=O.016). Phenindione provided safe and effective anticoagulation during pregnancy. A larger study is necessary to confirm the relationship between the dosage and outcome. © 2001 The International Society for Cardiovascular Surgery. Published by Elsevier Science Ltd. All rights reserved