M. Post, T. P. Singh, A. Horn
Apr 15, 1975
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Influential Citations
38
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Journal
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry
Abstract
The structure of imipramine hydrochloride, C19H24N2.HCI, monoclinic with space group P21/e and a= 11.303 (3), b=29-227 (8), c= 14.282 (3) .,?k, ,8= 130.91 (1) °, Z=8, was determined by multi-solution direct methods and refined by full-matrix least-squares and conjugate gradient methods to an R of 0-057 for 2880 counter reflexions. The two molecules in the asymmetric unit have slightly different conformations of the se~,en-membered hetero-ring and one molecule appears to exhibit a small movement in the dimethylene bridge. Angles between benzene ring planes are 130.3 and 123-0 °. The dimethylaminopropyl side chains exhibit different conformation and the amine nitrogen atoms and chloride ions form a layered arrangement in the lattice.