A. Hassan, R. Monroe, F. E. Guthrie
1969
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Journal
Canadian journal of physiology and pharmacology
Abstract
Acetanilide was investigated as a possible antidote against methanol poisoning in mice. The drug afforded significant protection, when administered intraperitoneally at a dosage of 100 mg/kg 30 min after the oral ingestion of methanol (1100 mg/kg). When administered after longer periods, acetanilide was of less protective value. The degree of protection seems to parallel the amount of nonmetabolized methanol remaining in the organism. The antidotal property of acetanilide is believed to be related to the inhibition of alcohol oxidation.