V. Narayanan, J. Bernstein, J. Williams
Feb 1, 1966
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0
Influential Citations
1
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Some 5-substituted-3–(trichloromethyl)-1,2,4-thiadiazoles were synthesized by the nucleophilic displacement of the CI − ion of 5-chloro-3-(trichloromethyl)-1,2,4-thiadiazole for evaluation as soil fungicides. An interesting O → N migration of the β -hydroxyethyl substituent was observed during the synthesis of 5-(2-hydroxyethoxy)-3-(trichloromethyl)-1,2,4-thiadiazole. All these compounds retained 60–80 per cent of the over-all fungicidal activity of the analogous 5-ethoxy-3-(trichloromethyl)-1,2,4-thiadiazole.