D. Mares, C. Romagnoli, A. Donini
Feb 1, 1996
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Canadian Journal of Microbiology
Abstract
The antifungal activity of 3-methyl-5-aminoisoxazole-4-thiocyanate was studied on Candida albicans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Rhodotorula glutinis. A significant inhibition of growth was evident in all yeasts. The ultrastructural modifications have demonstrated that the compound at half-minimum inhibitory concentration (MIC) dose (1.25 kg. mL-1) causes the transformation of R. glutinis from yeast to mycelium form by the formation of a germ tube. The accumulation of abnormal amounts of wall substances after treatment with the MIC is discussed in relation to ergosterol and chitin production.