T. Modena, F. Pavanetto, M. Mazza
Oct 1, 1994
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Citations
Journal
Farmaco
Abstract
Methylation of 1,3-dihydro-1-hydroxy-3-oxo-1-isobenzofurancarboxamides (A-I) yields 2-(2-arylamino-1,2-dioxoethyl)benzoic acid methylesters. The esters 1-7 allowed the evaluation of the intrinsic activity of 2-(2-arylamino-1,2-dioxoethyl)benzoic structure, to whom the antigravitropic effect of the carboxamides A-I may be probably assigned. The comparison of activities of methylesters 1-7 (B) and 8-14 (C) shows how conformational differences as those between the arylamino-1,2-dioxoethylic portion of B and the arylamino-2-oxoethylic portion of C may deeply effect phytotropin interaction with the receptor site.