J. Burckhalter, V. C. Stephens, L. A. R. Hall
May 1, 1950
Citations
0
Influential Citations
11
Citations
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
Although β-dimethylaminoethyl chloride hydrochloride is a very important intermediate which has been especially useful in the synthesis of various antihistaminic agents, publications mentioning its use often neglect to refer to a convenient method of preparation. A simplified laboratory procedure for the preparation of this intermediate is reported and a description is given of its use in the synthesis of two antihistamine-type compounds derived from carbazole and diphenylamine.