G. Ewart, N. Nasr, Hassan Mohammad Naif
Jun 1, 2004
Citations
4
Influential Citations
57
Citations
Journal
Antimicrobial Agents and Chemotherapy
Abstract
ABSTRACT We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.