N. Hirose, S. Kuriyama, Y. Kato
Feb 1, 1976
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A series of 2,3-dihydrobenzofuran-5-acetic acids and related compounds was prepared as potential antiinflammatory agents. As measured by the carrageenan-induced edema method for the preliminary screening test, introduction of a methyl group alpha to the acetic acid function enhanced the antiinflammatory activity, and alpha-(7-chloro-2,2-dimethyl-2,3-dihydrobenzofuran)-alpha-methyl-5-acetic acid (13a) showed the most potent activity in this series.