V. L. Gein, V. V. Yushkov, T. A. Splina
Nov 5, 2008
Citations
0
Influential Citations
9
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
A three-component reaction of acetylpyruvic acid esters, aromatic aldehydes, and heterylamines was used to synthesize 3-hydroxy-3-pyrrolin-2-ones containing heterocyclic substituents at the 1 position of the pyrroline ring. The effects of the heterocyclic substituent on the extent of anti-inflammatory and analgesic actions were studied.