E. de la Cuesta, P. Ballesteros, G. G. Trigo
Sep 1, 1984
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides (IX-XII) prepared from bicyclo[3.2.1]octan-3-one (I), were assayed in vitro against influenza A viruses. All materials showed activity similar to 1-adamantanamine hydrochloride. A 1H-NMR study revealed only one isomer at the spiro carbon atom.