Ankit J. Patel, Manish P. Patel, Amit Dholakia
Apr 10, 2021
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Quality indicators
Journal
Polycyclic Aromatic Compounds
Abstract
Abstract We have synthesized a new series of 7-chloroquinoline derivatives by a single step choro-amine coupling reaction. Compounds 3a–l was tested for in vitro antitubercular and antimalarial agent. Compounds 3a and 3 b were more active than rifampicin against M. tuberculosis H37Rv and compound 3a was more active against P. falciparum strain as compared to quinine. Furthermore, compounds 3b and 3c were found to possess excellent activity as compared to quinine. These compounds could be considered as a new broad spectrum antitubercular and antimalarial agent. All the synthesized compounds were confirmed by IR, Mass, 1HNMR and 13C NMR spectroscopy. Molecular docking studies were also done subsequently, using target, shikimate kinase (2IYZ) and hypoxanthine-guanine phosphoribosyltransferase (1BZY) enzyme to find the structural requirement for activity for these series of compounds.