A. David, K. Edwards, K. Fellowes
Jun 1, 1963
Citations
0
Influential Citations
62
Citations
Journal
Reproduction
Abstract
Summary. 17cc-Acetoxy-6 methyl pregna 4:6-diene-3:20-dione (B.D.H. 1298), has been given the approved name of Megestrol acetate. It appears to be the most potent anti-ovulatory compound so far reported. It also possesses high oral progestational properties, being more active in the Clauberg assay than medroxy progesterone acetate, commercial norethynodrel and dimethisterone given orally, and progesterone subcutaneously. It is non-toxic in mice ; prolonged admini¬ stration to rats caused no adverse effects except at high doses in females where some adrenal atrophy was observed. It has no anabolic, androgenic or oestrogenic properties and no virilizing effect on the developing foetus.