Zhou Dan
2011
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Quality indicators
Journal
Journal of Hainan Medical University
Abstract
Objective: To investigate the antioxidant capacity of 5,6-dimethyl-2,3-pyrazine amide.Methods: Luminol chemiluminescence and pyrogallol self-oxidation method were applied to detect the scavenging capacity of hydroxy radical and superoxide anion free radical.Results: 5,6-dimethyl-2,3-pyrazine amide can scavenge·OH in a dose-effect way with IC50 of 0.065 mg/mL;it′s also capable of scavenging superoxide anion free radicals in a concentration-depended way.At a concentration of 0.14 mg/mL,the clearance rate of O2 was 50%,when it increase to 0.39 mg/mL the clearance rate can be as high as 80%.Conclusions: 5,6-dimethyl-2,3-pyrazine amide is water-soluble substance with great potential of antioxidant capacity