G. Engel, U. Hofmann, Hugo Heidemann
Jun 1, 1996
Citations
12
Influential Citations
180
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
Antipyrine has been widely used as a probe drug for human oxidative drug metabolism. To evaluate the role of antipyrine as a model drug, we have identified the cytochrome P450 enzymes involved in 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation.