A. Andreani, D. Bonazzi, M. Rambaldi
Sep 21, 1982
Citations
0
Influential Citations
37
Citations
Journal
Archiv der Pharmazie
Abstract
The Vilsmeier reaction for the synthesis of the 5‐formylimidazo[2,1‐b]thiazoles 7–12 bearing a p‐substituted phenyl ring in position 6 is reported. These compounds were used for the synthesis of the thiosemicarbazones 7a‐12a, tosylhydrazones 7b‐12b and 5‐hydroxymethyl derivatives 13–18 which, in turn, were used as starting materials for preparing the methylcarbamic 13a‐18a, ethylcarbamic 13b‐18b and acetic esters 13c‐18c. Preliminary results in the P‐388 leukemia test are reported.