Aldo Andreanix, Giancarlo Scapini, I. Galatulas
Jul 1, 1983
Citations
0
Influential Citations
31
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The reaction between o-hydroxybutyrophenone and tris(2-chloroethyl)amine gave two analogues (II, V) of the well-known local anesthetic ketocaine (I). Compounds II and V showed interesting antitumor activity in mice implanted with Ehrlich ascites tumor cells (% T/C = 149 at 5 mg/kg and 171 at 50 mg/kg, respectively). Further studies on the pharmacological behavior of these new compounds are in progress.