G. Gale, E. M. Walker, Alayneb . Smith
Apr 1, 1971
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0
Influential Citations
6
Citations
Quality indicators
Journal
Proceedings of the Society for Experimental Biology and Medicine
Abstract
Summary The photochemical reaction product of ammonium hexachloroiridate(IV) retards the rate of development of the Ehrlich ascites carcinoma in BALB/c mice and, to a lesser degree, the development of the L1210 leukemia in BDF1 mice. Of the various dos age regimens examined, a maximum of 140% increase of mean survival time was obtained with mice bearing the Ehrlich carcinoma, but only a 20% increase was demonstrated with mice bearing the L1210 leukemia. Blastogenic transformation of phytohemagglutinin-stimulated human lymphocytes in culture was also inhibited by the product, as evidenced by a reduced rate of incorporation of thymidine into cultured cells. No evidence was obtained that the product was a selective inhibitor of deoxyribonucleic acid synthesis; rates of ribonucleic acid and protein synthesis were inhibited to the same extent as the rate of deoxyribonucleic acid synthesis in both cultured human lymphocytes and Ehrlich ascites carcinoma cells in vitro.