Jian Tang, Huiliang Li, Yun-Heng Shen
Dec 9, 2009
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1
Influential Citations
33
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Quality indicators
Journal
Phytotherapy Research
Abstract
Ten steroidal alkaloids – cyclopamine, veratramine, jervine, 3, 15‐diangyloylgermine, 3‐angyloylzygadenine, 3‐veratroyl zygadenine, 15‐veratroylgermine, germine, veratrosine and pseudojervine – from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC‐1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg‐1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 μM. Copyright © 2009 John Wiley & Sons, Ltd.