S. Cutbush, R. Kuroda, S. Neidle
Jun 1, 1983
Citations
0
Influential Citations
25
Citations
Journal
Journal of inorganic biochemistry
Abstract
The anti-tumour compound ethylenediamine platinum (II) malonate has been examined by x-ray crystallography. The molecular structure has a square-planar arrangement around the platinum atom, with the malonate group in a boat conformation and cis to the ethylenediamine group. Solution studies have shown that the malonate ion may be readily displaced from the complex, especially by chloride ion, and at low pH. The implications of this finding for in vivo drug administration are discussed.