T. Bardos, A. Segaloff, J. L. Ambrus
Feb 28, 1959
Citations
0
Influential Citations
12
Citations
Journal
Nature
Abstract
5-MERCAPTOURACIL, a structural analogue of thymine, was synthesized several years ago1,2. This compound (and its disulphide) inhibited the growth of Lactobacillus leichmannii at 1–3 µgm./ml. concentration, and this inhibition could be reversed ‘competitively’ with thymine. It was tested in several experimental mouse tumours; in some cases, it caused tumour inhibition of borderline significance, at less than the maximum tolerated dose3.