E. F. Jansen, M. D. Nutting, A. Balls
Sep 1, 1947
Citations
0
Influential Citations
8
Citations
Journal
Journal of Biological Chemistry
Abstract
Diisopropyl fluorophosphate (DFP) and hexaethyl tetraphosphate (HETP) have been shown to be remarkedly potent inhibitors of cholinesterase both in vitro-and in vivo.192 Higher concentrations of DFP were needed for the inhibiton of true cholinesterase (brain and erythrocyte) than for the pseudocholinesterase (serum). The DFP inhibition was irreversible as opposed to eserine inhibition. With the serum enzyme the presence of DFP did not produce a progressive inactivation, but rather the hydrolysis