M. Sommer, M. Begtrup, K. P. Boegesoe
Aug 1, 1990
Citations
0
Influential Citations
9
Citations
Journal
Journal of Organic Chemistry
Abstract
(2-Cyanoaryl)arylacetonitriles, obtained from o-halogen-substituted cyanoaromatics and arylacetonitriles may be alkylated with methyl chloroacetate. Subsequent abstraction of the proton adjacent to the ester group followed by attack of the anion at the aromatic cyano group gives rise to annulated 1-aminocyclopentenes by a Dieckmann-type reaction. The homologous esters similarly produce annulated 1-aminocyclohexenes. The generality of this annulation method is demonstrated