A. Ishii, Masatomi Kanai, M. Yasumoto
Apr 1, 2004
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0
Influential Citations
2
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Synthetic application of 3,3-dichloro-1,1,1-trifluoroacetone (DCTFA) and 3,3,3-trichloro-1,1,1-trifluoroacetone (TCTFA) for industrially important trifluorolactic acid derivatives is described. Trifluorolactic acid was obtained by hydrolysis of DCTFA under basic conditions. On the other hand, α-substituted trifluorolactic acid derivatives, such as α-methyltrifluorolactic acid and Mosher’s acid, were obtained by addition reaction between TCTFA and carbon nucleophiles, followed by subsequent transformation of trichloromethyl group.