M. Lebwohl
Sep 1, 1997
Citations
1
Influential Citations
56
Citations
Quality indicators
Journal
Journal of the American Academy of Dermatology
Abstract
BACKGROUND Side effects of topical corticosteroids limit their long-term use. Calcipotriene/calcipotriol (Dovonex/Daivonex) ointment is not associated with any of the side effects of corticosteroids and has been shown to thicken the skin in contrast to the cutaneous atrophy caused by topical steroids. OBJECTIVE We attempted to determine whether the addition of calcipotriene to a regimen of topical steroids results in an improved benefit/risk ratio. METHODS Published and unpublished data on combination regimens were reviewed. RESULTS In long-term regimens for psoriasis, substituting calcipotriene for topical corticosteroids may result in a steroid-sparing effect. Conversely, topical corticosteroids may suppress the development of local cutaneous irritation that occurs in patients treated with calcipotriene ointment. CONCLUSION Psoriasis regimens combining calcipotriene ointment with superpotent steroids such as halobetasol ointment can result in greater improvement and fewer side effects.