Z. Ru
2014
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Journal
Journal of Guangzhou University
Abstract
6,6'-dihydroxy-5,5'-biquinoline( BIQOL) is a new chiral ligands with C2 symmetry axis. In order to extend its application,the titanium complexes of BIQOL were applied in the asymmetric Friedel-Crafts reaction between a variety of N,N-dialkylanilins and ethyl glyoxylate which were reported for the first time. Good enantioselectivity up to 70. 1% had been given under the optimized conditions. Moreover,the reaction could also be carried out without Ti( OiPr)4,which gave an enantioselectivity of 14.6%.