T. M. Stevenson, Brett A. Crouse, Tho V. Thieu
Aug 30, 2005
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Journal
ChemInform
Abstract
Pyridazinones have played an important role in the chemistry of crop protection products. The nucleophilic displacement chemistry of 4,5-dihalo-3-(2H)-pyridazinones has long been exploited for the synthesis of both commercially important herbicides and insecticides. Two examples are shown in Figure 1. It follows that the pyridazinone nucleus confers biological and physical properties to molecules that are favorable for their development as crop protection agents. Therefore, we wished to extend halopyridazinone chemistry from nucleophilic displacement to metal mediated processes for C-C bond formation in hopes of discovering new classes of biologically active pyridazines.