Z. Pianowski, K. Staliński
Aug 30, 2005
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ChemInform
Abstract
New N-coordinated dimethyl and di-n-butyl tin hydrides containing the oxazole moiety appeared to be useful in radical cyclizations of acyclic dihalides at the steady state. Both the hydrides were prepared in three steps starting from (-)-(S)-(2-bromophenyl)-4-isopropyl-4,5-dihydrooxazole. The advantages of the hydrides are at least twofold. First, a resolution of the radical intermediates allows generating higher stereomeric excess than in the case of commercially available hydrides. Second, tin by-products are easily removed.