Wang De-xin
2005
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Journal
Chemical Reagents
Abstract
Several bases,such as diisopropylamine (DIPA),Cs 2CO 3,diethylamine(DEA),triethylamine(tea),dicyclohexylamine(DCHA) and N-methylmorpholine (NMM),as the reagents to promote the esterification of Boc-amino acid with Merrifield resin were tested.Based on the weight-gaining of the resin and nitrogen elemental analysis,the efficiency of DIPA in related reaction was the same as that of Cs 2CO 3.Considering the easiness in manipulation and low cost,DIPA promoted process would be more suitable for large scale production of Merrifield resin bound Boc amino acids.