R. Whiteside, David E. Games, C. Strawson
Jun 30, 2001
Citations
0
Influential Citations
7
Citations
Journal
Journal of Liquid Chromatography & Related Technologies
Abstract
High-speed Countercurrent Chromatography (HSCCC) has been applied to the separation of three of the possible diastereomers of Lisinopril Diketopiperazine. The diastereomers occur in the synthesis of the ACE inhibitor, Lisinopril, as a result of over heating during a distillation process. Their levels are a measure of process control and typically should be held below 0.2% w/w w.r.t. lisinopril. Pure quantities of the diastereomers are required to serve as standards in determining levels in the final bulk drug. Difficulties often arise during the current procedure for the purification of the pure standards. The potential of HSCCC was examined as an alternative technique for their separation.