A. Shuker, M. Siegel, D. Matthews
Sep 1, 1997
Citations
0
Influential Citations
37
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A 48 compound library of structurally diverse ethanolamines was prepared using a parallel synthesis approach. The synthetic paradigm employed a solution phase epoxide-opening reaction followed by rapid purification by ion exchange chromatography to yield products with near-analytical purity. An array of epoxides and primary amines, arranged in an 8×6 matrix, were reacted in the presence of an in situ silylating agent to form 48 individual compounds with an average yield of 75% and an average purity of 92.3%. © 1997 Elsevier Science Ltd.