F. Cruz, Clarissa M. Magsipoc, Francez Eunika B. Alinea
Nov 1, 2016
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Journal
2016 IEEE Region 10 Conference (TENCON)
Abstract
This work presents the design of application specific integrated circuit (ASIC) intended for L-Asparagine measurement, using ion sensitive field effect transistor (ISFET) as biosensor. The L-Asparagine is an amino acid that promotes the growth of cancer cells in leukemia patients. The designed ASIC is comprised of ISFET bridge-type readout circuit, inverting operational amplifier, and peak detector circuit. The L-Asparagine concentrations are translated into pH levels. SPICE simulations showed a sensitivity of −72.78 mV/pH with a linear correlation of almost 1 across the output of the designed ASIC.