P. Van de Vijver, Liesbeth Scheer, J. V. van Beijnum
Aug 22, 2012
Citations
0
Influential Citations
5
Citations
Journal
Chemical communications
Abstract
The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.