Y. Funahashi, Y. Masaki, Y. Tokunori
2013
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Journal
Neurourology and Urodynamics
Abstract
Hypothesis / aims of study Oral rebamipide has been used for treatment of gastritis and ulcer disease. Local application of rebamipide is effective treatment for the tissue injuries in the colon, lungs, kidneys, liver, and cornea in animal models, and it was recently approved for treating dry eye in Japan. Because the mechanism of action of rebamipide includes suppression of inflammation, inhibition of free radicals, and acceleration of wound healing, local administration of rebamipide may suppress bladder inflammation. Thus, we investigated the effects of intravesical application of rebamipide on bladder overactivity and inflammation using a chemically induced rat cystitis model.