K. Borsuk, F. L. Delft, I. Eggen
Apr 26, 2004
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron Letters
Abstract
The use of differently substituted 2-(trimethylsilyl)ethyl esters for C-terminal protection in peptide synthesis has been investigated. While the use of the unsubstituted 2-(trimethylsilyl)ethyl ester resulted in a substantial amount of diketopiperazine at the dipeptide stage, use of the corresponding methyl-substituted silyl ester gave a significant reduction of this undesired pathway. Both esters could be deprotected by fluoride-induced cleavage under mild conditions.