Hsueh-Yun Lee, L. Lee, C. Nien
Nov 26, 2012
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Organic & biomolecular chemistry
Abstract
A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3' of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3'-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.