A. M. Jadhav, Yeong-Il Kim, K. Lim
Feb 7, 2018
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple, efficient, eco-friendly, and cost-effective method has been developed for the synthesis of N -methyl-3-nitro-aryl-benzo[4,5]imidazo[1,2- a ]pyrimidin-2-amine derivatives using 2-aminobenzimidazole, aldehydes and ( E )- N -methyl-1-(methylthio)-2-nitroethenamine, in the presence of catalytic amount of p -toluenesulfonic acid ( p -TSA) in ethanol at 80 °C conditions. The advantages of this method are the use of an inexpensive and readily available catalyst, shorter reaction times, a wide range of functional group tolerance, and high yield of products via a simple experimental and work-up procedure.