Bhushan B Borase, H. M. Godbole, G. Singh
Jan 2, 2020
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0
Influential Citations
6
Citations
Journal
Synthetic Communications
Abstract
Abstract A novel, efficient and concise synthesis of chirally pure quinapril hydrochloride is described. The key step is the formation of α-amino amide backbone in one step using Ugi three component reaction. This method allows short access to α-amino amide chain which is a part of many drugs used for treatment of high blood pressure. A large molecular library can be synthesized by changing the components in Ugi reaction. GRAPHICAL ABSTRACT