J. Kaur, Paras Famta, N. Khurana
2020
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Abstract
Abstract 4-Hydroxycoumarins came into the limelight when they caused internal bleeding to cattle in the United States and southern Canada. Warfarin, a coumarin derivative, was first used as a rodenticide and dramatically became an oral anticoagulant in the 1950s. These agents are natural fungal metabolites produced from coumarin, which is a precursor. These have been successfully used in medical conditions such as cardiac disease, pulmonary embolism, stroke, thrombophlebitis, etc., and derive big revenue in the pharmaceutical industry. After successful application as an anticoagulant, this class has been at the center of attention of various research groups across the globe. These are being proven to not only be nontoxic, economical, and ecofriendly, but also as sustainable agents. Current research trends show the great potential of this metabolite as an anticancer, antiarthritic, antipyretic, and antimicrobial agent. This chapter will discuss the present-day application of 4-hydroxycoumarins and the enormous potential it holds for the future.