H. Beraldo
Sep 15, 2020
Citations
1
Influential Citations
9
Citations
Journal
Coordination Chemistry Reviews
Abstract
Abstract Although radioactive 111In(III) compounds have been extensively investigated for labeling of cells in detection and diagnosis of infections and inflammation, the pharmacological applications of non-radioactive indium(III) complexes remain so far almost unexplored. In the present work the main potential applications of these complexes as antimicrobial and antineoplastic agents are reviewed, together with their interactions with different biomolecules. Some aspects of the behavior of indium(III) complexes in biological aqueous media are also mentioned. The interactions of indium(III) complexes with transferrin are discussed, with emphasis in the potential applications of these compounds for the treatment of tumors which overexpress transferrin receptors. Hence, the affinity of indium(III) complexes for transferrin might be explored in the design of selective antineoplastic agents. Some preliminary information on the toxicity of these complexes is given as well, which must be taken into consideration in evaluating the efficacy, safety and druggability of indium(III) complexes. Since 111In compounds are already used in clinics, non-radioactive indium(III) complexes might be an attractive platform for developing novel metal-based antitumor drug candidates.