C. Hulme, Jo-Sen Peng, B. Louridas
Oct 29, 1998
Citations
0
Influential Citations
49
Citations
Journal
Tetrahedron Letters
Abstract
Abstract This communication reveals a novel application of the ‘so-called’ convertible isonitrile for the solution phase generation of ketopiperazine libraries. Use of mono N-BOC diamines in the Ugi multi-component reaction (MCR), followed by BOC removal and base treatment (a ‘3 step, 1-pot procedure’) affords ketopiperazines in good yield. The generality of this procedure was further explored revealing novel routes to dihydroquinoxalinones and 1,4-benzodiazepines respectively