Y. Gong, Katsuya Kato
Oct 31, 2004
Citations
0
Influential Citations
17
Citations
Journal
ChemInform
Abstract
In this review, recent application of trifluoroacetaldehyde ethyl hemiacetal (TFAE) in the preparation of α-trifluoromethyl alcohols and α-trifluoromethyl amines, especially by the direct regioselective and stereoselective substitution of TFAE and its derivatives like imines with various aromatic and heteroaromatic compounds, is reviewed. Moreover, some useful methods for preparing important potentially bioactive fluorinated compounds, such as o- and p-substituted fluoroalkylphenols and β-trifluoromethyl amino acids, are also introduced.