H. Schick, R. Ludwig
1992
Citations
0
Influential Citations
9
Citations
Journal
Synthesis
Abstract
Ethyl 2-bromoalkanoates react with zinc and succinic anhydride in dimethylformamide forming 2-substituted 1-ethyl hydrogen 3-oxoadipates (hexanedioates) isolable in a yield of 56-78%. When subjected to decarboxylative saponification, they afford 4-oxoalkanoic acids in overall yields of 50-72%