O. Grygorenko, I. Komarov, C. Cativiela
Jul 2, 2009
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
A novel approach to 2-azabicyclo[2.2.1]heptane-1-carboxylic acid (2,4-ethanoproline) is reported starting from (2S,4R)-4-hydroxyproline. The synthetic scheme consists of 10 steps and results in 22% total yield of the title compound. Enantiomeric purity of the product is checked by chiral stationary phase HPLC.