F. Bracher, T. Papke
Sep 1, 1994
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract (S)-2-Methyl-3-(2-thiophene)-1-propanol was prepared by an improved baker's yeast-mediated asymmetric reduction of the corresponding 2,3-unsaturated aldehyde. (R)-2-Methyl-3(2-thiophene)-1-propanol was obtained by enzymatic kinetic resolution of the racemic alcohol in an organic solvent. Both enantiomers are versatile chiral building blocks for the synthesis of 3-alkyl pyridine alkaloids.