P. Campiglia, I. Gomez-Monterrey, L. Longobardo
Feb 9, 2004
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient approach for the synthesis of cyclic peptides containing unnatural thioether side-chain bridges, based on the use of (2 S )-9-fluorenylmethyl-2-[( tert -butoxycarbonyl)amino]-4-iodobutanoate and its homologue 5-iodopentanoate, derived from Boc- l -Asp-OFm and Boc- l -Glu-OFm, respectively, is reported. The synthesis was performed by a tandem combination of solid-phase peptide synthesis and microwave-assisted cyclization strategy.